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Articles by Michael D. Bartberger Muck Rack

Articles by Michael D. Bartberger on Muck Rack. Find Michael D. Bartberger's email address, contact information, LinkedIn, Twitter, other social media and more.

Asymmetric Hydrogenation of Isoquinolinium Salts Catalyzed

Alexia Kim, Aurapat Ngamnithiporn, Eric R Welin, Martin Daiger, Christian Grünanger, Michael D. Bartberger, Scott C Virgil, Brian M. Stoltz, Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines, Supporting Information Volume 52, Issue 7. February 11, 2013 Asymmetric Hydrogenation of Quinolines and Isoquinolines Active ingredient:Optically active tetrahydroquinolines and tetrahydroisoquinolines can be obtained by the asymmetric hydrogenation of quinolines and isoquinolines with chloroformates as the activating reagent (e.g., ClCO 2 Bn, see scheme). The method has been applied to the asymmetric synthesis of several naturally occurring alkaloids. Bn=benzyl

Asymmetric Hydrogenation of Quinolines and Isoquinolines

Active ingredient:Optically active tetrahydroquinolines and tetrahydroisoquinolines can be obtained by the asymmetric hydrogenation of quinolines and isoquinolines with chloroformates as the activating reagent (e.g., ClCO 2 Bn, see scheme). The method has been applied to the asymmetric synthesis of several naturally occurring alkaloids. Bn=benzyl ChemInform Abstract:Primary Amine, Thiourea-Based Dual ChemInform Abstract:Primary Amine, Thiourea-Based Dual Catalysis Motif for Synthesis of Stereogenic, All-Carbon Quaternary Center-Containing Cycloalkanones.

ChemInform Abstract:Synthesis of Benzo- and Naphtho

ChemInform Abstract:Synthesis of Benzo- and Naphtho-Fused Bicyclo[n.3.1]alkane Frameworks with a Bridgehead Nitrogen Function by Palladium-Catalyzed Intramolecular -Arylation of -Nitroketones. Copper Catalyzed Assembly of NAryloxazolidinones The total synthesis of oxazolidinonebased pharmaceuticals, linezolid, tedizolid and rivaroxaban is reported. They are synthesized using a recently reported coppercatalyzed onepot cyclization and arylation as the key step to construct the Naryloxazolidinone core.Active pharmaceutical ingredients (API) were synthesized from a common synthetic pool of a simple protected amino alcohol

Enantioselective Alkylation of Acyclic ,Disubstituted

Wen-Bo Liu, Corey M. Reeves, Scott C. Virgil, Brian M. Stoltz, Construction of Vicinal Tertiary and All-Carbon Quaternary Stereocenters via Ir-Catalyzed Regio-, Diastereo-, and Enantioselective Allylic Alkylation and Applications in Sequential Pd Catalysis, Journal of the American Chemical Society, 10.1021/ja4052075, 135, 29, (10626-10629), (2013). Enantioselective Decarboxylative Alkylation Reactions Aurapat Ngamnithiporn, Toshihiko Iwayama, Michael D. Bartberger, Brian M. Stoltz, Enantioselective synthesis of highly oxygenated acyclic quaternary center-containing building blocks via palladium-catalyzed decarboxylative allylic alkylation of cyclic siloxyketones , Chemical Science, 10.1039/D0SC04383D, (2020).

Enantioselective Decarboxylative Alkylation Reactions

Nov 14, 2011 · Eric J. Alexy, Tyler J. Fulton, Haiming Zhang, Brian M. Stoltz, Palladium-catalyzed enantioselective decarboxylative allylic alkylation of fully substituted N -acyl indole-derived enol carbonates , Chemical Science, 10.1039/C9SC01726G, (2019). Enantioselective Decarboxylative Alkylation Reactions Nov 14, 2011 · Wen-Bo Liu, Corey M. Reeves, Scott C. Virgil and Brian M. Stoltz, Construction of Vicinal Tertiary and All-Carbon Quaternary Stereocenters via Ir-Catalyzed Regio-, Diastereo-, and Enantioselective Allylic Alkylation and Applications in Sequential Pd Catalysis, Journal of the American Chemical Society, 10.1021/ja4052075, 135, 29, (10626-10629

Enantioselective Pd-Catalyzed Decarboxylative Allylic

Alexy EJ 1, ' ' Virgil SC 1 Bartberger MD 2, Stoltz BM Journal Article, Research Support, N.I.H., Extramural DOI:10.1021/acslett.7b02354. Abstract. A catalytic, enantioselective decarboxylative allylic alkylation of 4-thiopyranones is reported. The -quaternary 4-thiopyranones produced are challenging to access by standard enolate Enantioselective Pd-Catalyzed Decarboxylative Allylic Supporting Information for Alexy, Virgil, Bartberger, and Stoltz SI1 Supporting Information for Enantioselective Pd-Catalyzed Decarboxylative Allylic Alkylation of Thiopyranones. Access to Acyclic, Stereogenic -Quaternary Ketones. Eric J. Alexy,a Scott C. Virgil,a Michael D. Bartberger

Enhancing Effects of Salt Formation on Catalytic Activity

Nov 28, 2014 · Alexia Kim, Aurapat Ngamnithiporn, Eric R Welin, Martin Daiger, Christian Grünanger, Michael D. Bartberger, Scott C Virgil, Brian M. Stoltz, Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines, Supporting Information Volume 21, Issue 5. January 26, 2015. Pages Enhancing Effects of Salt Formation on Catalytic Activity Nov 28, 2014 · Alexia Kim, Aurapat Ngamnithiporn, Eric R Welin, Martin Daiger, Christian Grünanger, Michael D. Bartberger, Scott C Virgil, Brian M. Stoltz, Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines, Supporting Information Volume 21, Issue 5. January 26, 2015. Pages

Eric J. Alexy's research works California Institute of

Eric J. Alexy's 9 research works with 83 citations and 152 reads, including:PalladiumCatalyzed Enantioselective Decarboxylative Allylic Alkylation of Protected BenzoinDerived Enol Carbonates Michael D. Bartberger Muck Rackpubs.acs Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States Department of Molecular Engineering, Therapeutic Discovery, Amgen, Inc., 1 Amgen Center Drive, M/S 29-M-B, Thousand Oaks, California 91320, United States

New multicomponent approach for the creation of chiral

Apr 01, 2006 · Supporting Mentioning Disputing 0 25 0 Article citations Alexy EJ, Virgil SC, Bartberger MD, Stoltz BM. Org Lett, 19(19):5007-5009, and in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine New multicomponent approach for the creation of chiral Apr 01, 2006 · Supporting Mentioning Disputing 0 25 0 Article citations Alexy EJ, Virgil SC, Bartberger MD, Stoltz BM. Org Lett, 19(19):5007-5009, and in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine

Nickel-catalyzed enantioselective allylic alkylation of

The first nickel-catalyzed enantioselective allylic alkylation of lactone and lactam substrates to deliver products bearing an all-carbon quaternary stereocenter is reported. The reaction, which utilizes a commercially available chiral bisphosphine ligand, proceeds in good yield with a high level of enantios Palladium-catalyzed enantioselective decarboxylative Palladium-catalyzed enantioselective decarboxylative allylic alkylation of fully substituted N-acyl indole-derived enol carbonates. Eric J. Alexy a, Tyler J. Fulton a, Haiming Zhang * b and Brian M. Stoltz * a a Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena

Palladium-catalyzed enantioselective decarboxylative

The first enantioselective palladium-catalyzed decarboxylative allylic alkylation of fully substituted N-acyl indole-derived enol carbonates forming acyclic all-carbon quaternary stereocenters is reported.Excellent yields up to 99% and enantioselectivities up to 98% ee are obtained through the use of a new electron-deficient phosphinoxazoline (PHOX) ligand. Palladium-catalyzed enantioselective decarboxylative The first enantioselective palladium-catalyzed decarboxylative allylic alkylation of fully substituted N-acyl indole-derived enol carbonates forming acyclic all-carbon quaternary stereocenters is reported.Excellent yields up to 99% and enantioselectivities up to 98% ee are obtained through the use of a new electron-deficient phosphinoxazoline (PHOX) ligand.

PalladiumCatalyzed Enantioselective Decarboxylative

Benzoins are a preeminent motif in organic chemistry that are used as synthetic intermediates to access a variety of useful structures. 1 As a result, extensive efforts toward the asymmetric synthesis of benzoin derivatives have been reported, including enantioselective benzoin condensations, 2 reductions of diketones, 3 and enzymecatalyzed kinetic resolutions. 4 However, the direct PalladiumCatalyzed Enantioselective Decarboxylative Benzoins are a preeminent motif in organic chemistry that are used as synthetic intermediates to access a variety of useful structures. 1 As a result, extensive efforts toward the asymmetric synthesis of benzoin derivatives have been reported, including enantioselective benzoin condensations, 2 reductions of diketones, 3 and enzymecatalyzed kinetic resolutions. 4 However, the direct

Silver Lake candlelight vigil held to support BLM Silver

Silver Lake-- A candlelight vigil and march was held Sunday night at the Silver Lake Reservoir to honor those who have been killed by police and to support the Black Lives Matter movement. Marchers, estimated to be in the hundreds, holding candles and chanting walked down West Silver Lake Drive. Synthesis and antiinflammatory activity of Eric J. Alexy, Scott C. Virgil, Michael D. Bartberger, and Brian M. Stoltz . Enantioselective Pd-Catalyzed Decarboxylative Allylic Alkylation of Thiopyranones. Access to

Synthesis and antiinflammatory activity of

Eric J. Alexy, Scott C. Virgil, Michael D. Bartberger, and Brian M. Stoltz . Enantioselective Pd-Catalyzed Decarboxylative Allylic Alkylation of Thiopyranones. Access to Synthesis, Characterization, and Optimization for in Vivo Bis-arylidenecycloalkanones structurally related to the nonselective isopeptidase inhibitor G5 were synthesized and tested for cytotoxic activity against glioblastoma cells. Cytotoxicities correlate well with Hammett constants for substituted arylidene groups, confirming the proposed inhibition mechanism. A new inhibitor (2c) based on the 4-hydroxycyclohexanone scaffold, which favors

Synthesis, Characterization, and Optimization for in Vivo

Bis-arylidenecycloalkanones structurally related to the nonselective isopeptidase inhibitor G5 were synthesized and tested for cytotoxic activity against glioblastoma cells. Cytotoxicities correlate well with Hammett constants for substituted arylidene groups, confirming the proposed inhibition mechanism. A new inhibitor (2c) based on the 4-hydroxycyclohexanone scaffold, which favors Synthesis, Characterization, and Optimization for in Vivo Find more information about Crossref citation counts. » Supporting Information Supporting Information Get e-Alerts. Download Hi-Res Image Download to MS-PowerPoint Cite This:J. Med. Chem. 2015 58 4 1691 Eric J. Alexy, Scott C. Virgil, Michael D. Bartberger, and Brian M. Stoltz .

Synthesis, Characterization, and Optimization for in Vivo

Find more information about Crossref citation counts. » Supporting Information Supporting Information Get e-Alerts. Download Hi-Res Image Download to MS-PowerPoint Cite This:J. Med. Chem. 2015 58 4 1691 Eric J. Alexy, Scott C. Virgil, Michael D. Bartberger, and Brian M. Stoltz . Supporting Information of Alexy, Virgil, Bartberger, and Supporting Information of Alexy, Virgil, Bartberger, and Stoltz SI24 13C NMR (100 MHz, CDCl 3) of compound 2b. Infrared spectrum (Thin Film, NaCl) of compound 2b.

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